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The 3D Cell Culture Market Projected to Grow at a CAGR of 15.07% and Generate Revenue of $5,656.7 million by 2031

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The global 3D cell culture market share is predicted to be valued at $ 5,656.7 million by 2031, surging from $1,495.0 million in 2021 at a noteworthy CAGR of 15.07%.

Impact Analysis of COVID-19 on the 3D Cell Culture Market

The impact of COVID-19 on the 3D cell culture market affected a wide range of businesses worldwide. Manufacturing facilities throughout the world were shut down during the early stages of the epidemic. Furthermore, the financial collapse that resulted from the pandemic might create significant delays in the commercialization of the healthcare business. On the contrary, small manufacturers and entrepreneurs have a lot of opportunity in the growth of 3D cell culture market to come up with cost-effective methods for generating 3D cell culture market demand for goods. The demand from clinical and diagnostic facilities is steadily increasing, which may encourage new firms to enter the market with innovative products. The high utility of 3-dimensional models for research on COVID-19 and respiratory illnesses is projected to provide considerable potential for the global 3D cell culture market growth. Air-liquid and airway interface organoids have been employed as tools for the development and discovery of antiviral medicines as well as experimental virology platforms to conduct research on the immune responses and infectivity of SARS-CoV-2. Scaffold-based and scaffold-free approaches enable the bio-fabrication of realistic models that may be exploited to create innovative treatments and vaccines against COVID-19.

However, several initiatives launched by the Jellagen Limited company are helping society recover from pandemic. For instance, in January 2021, Jellagen Limited, a biotechnology company that produces high-value collagen type 0 generated from jellyfish, announced the release of JellaGel Hydrogel, a 3D hydrogel. JellaGel offers clients a hydrogel that is non-mammalian, natural, consistent, biochemically simple, and simple to use.

Global 3D Cell Culture Market Analysis

The increased focus on developing alternatives to animal testing is expected to boost the 3D cell culture market share during the projected period. This is due to regulatory agencies' increased attempts to replace, reduce, and refine animal usage as well as rehabilitation for animals used in research. Furthermore, non-animal models/technologies such as cell cultures, computer models, human tissues, and volunteer studies that efficiently transfer toxicological and pharmacological data to people are predicted to support the demand for alternatives to animal testing. The 3D cell culture technique is the most efficient way that has gained popularity because it is physiologically realistic, better represents in vivo tissue, and has more convenient characteristics than other alternative methods. Furthermore, rise in applications of the 3D cell culture such as tissue engineering and immunohistochemistry, drug discovery, stem cell research, and organs-on-chips, are projected to promote global 3D cell culture market size expansion soon.

The costs of 3D cell cultures are usually kept high, discouraging end-users from purchasing the equipment. Furthermore, valid issues include the high costs involved with assay validation, linking to previous 2D culture data, and analytical techniques. The coating on the 3D models stops the reagents from entering the spheroid's base. Furthermore, incorrect results were obtained when the assays used were substandard. The aforementioned impediment would discourage potential end-users and restrict global 3D cell culture market share growth.

3D composite scaffolds offer numerous varied properties due to recent developments. It would be extremely beneficial to develop therapies for nerve diseases and spinal cord injury (SCI) using cell transplantation and biomaterials. The most notable benefit of 3D cell culture is that its qualities can be easily altered by adjusting its structure and composition. These essential applications are expected to generate tremendous prospects for the global 3D cell culture industry growth.

Global 3D Cell Culture Market Value, Segmentation

The global 3D cell culture market growth is segmented based on product, application, end user, and region.


The product segment is further classified into scaffold-based 3d cell culture, scaffold-free 3d cell culture, and microfluidic organ-on-a-chip models. Among these, the scaffold-free 3d cell culture sub-segment is anticipated to have a dominant market share in 2021. 3D cells cultured on pre-fabricated scaffolds or matrices created to replicate the in vivo ECM can be used to produce 3D tumor and tissue models. To build 3D cultures, cells connect, move, and fill the interstices inside the scaffold. The scaffolds are utilized as a physical support system for in vitro cell growth and have showed promise for application in vivo tissue regeneration due to their ability to reproduce the natural physical and structural environment of live tissue. There are several geometric arrangements of frequently included polymers such as polystyrene (PS) and polycaprolactone (PCL).


The application segment is further classified into cancer research, stem cell research, drug discovery, and regenerative medicine. Among these, the cancer research sub-segment is anticipated to have a dominant market share in 2021. Cancer research may become more cost-effective and accessible with the creation of in vitro 3D cell culture market size models that boost the probability of preclinical drug research representing human outcomes in drug trials and perhaps eliminate the requirement for animal experiments. However, the application of innovative 3D cell culture models in cancer research is still limited by model repeatability, which is required for specialized training, and throughput restrictions. The development and commercialization of 3D bioprinting technologies provides an interesting response to these challenges.

End User:

The end-user segment is further classified into biotechnology and pharmaceutical companies’ contract research laboratories, hospitals, diagnostic centers, and academic institutes. Among these, the biotechnology and pharmaceutical sub-segment is anticipated to have a dominant market share in 2021. The development of a significant number of biotechnology and pharmaceutical industries, growth in R&D investment in these sectors, and a rising preference for alternative testing models over animal procedures are primary market drivers. Compared to 2D cell culture, 3D cell culture provides advantages in terms of suitable oxygen and nutrient gradients, realistic cell-to-cell interactions, and non-uniform access of cells within a spheroid to a drug. As a result of these factors, 3D cell culture is more suited for drug discovery and development, leading in rise in demand. These advantages of 3D cell culture techniques are anticipated to generate huge 3D cell culture market size growth in the future.


The 3D cell culture market analysis in Asia-Pacific is projected to show the fastest growth. Due to the rise in number of pharmaceutical discoveries and the growing importance of the biotechnology sector, this region offers a substantial market potential for 3D cell culture. As a result of the rise in demand for stem cell, regenerative medicine, and cell therapies, a certain number of research and development initiatives are further being launched in nations such as South Korea. The Japanese government is concentrating more on cell-based regenerative medicine, and the nation is also trying to introduce innovative products to the market.

Key Players in the Global 3D Cell Culture Market

Some of the leading 3D cell culture market players are

  • Corning Incorporated
  • Thermo Fisher Scientific
  • TissUse GmbH
  • 3D Biotek
  • Hµrel Corporation
  • QGel SA
  • SynVivo
  • Advanced BioMatrix
  • Greiner Bio-One International
  • Lonza

In December 2021, Boston, Mass., CellPort Software, a SaaS firm that digitizes workflows for cell research and manufacturing, joined the Tetra Partner Network (TPN) to speed up the delivery of cell-based medicines, according to the R&D Data Cloud company.

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