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Label-free Array System Market Report


Label-free Array System Market by Type (Surface Plasmon Resonance, Bio-layer Interferometry, Cellular Dielectric Spectroscopy, and Others), Application (Drug Discovery, Protein Interface Analysis, Antibody Characterization, and Others), End-user Scope (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, CRO, and Others), and Region (North America, Europe, Asia-Pacific, and LAMEA): Opportunity Analysis and Industry Forecast, 2023-2032


Pages: 245

Sep 2023

 Label-free Array System Overview

A "Label-free Array System" is an analytical technology used in biotechnology and biochemistry to study molecular interactions without fluorescent or radioactive labels. Researchers would attach labels to molecules of interest in conventional assays to investigate their interactions with other molecules. However, label-free array systems eliminate the need for these labels, simplifying the process. These systems employ surface chemistries, microarrays, or biosensors to detect changes in the physicochemical properties of molecules during interactions. Standard label-free array technologies include Surface Plasmon Resonance (SPR), Bio-layer Interferometry (BLI), Quartz Crystal Microbalance (QCM), and Electrochemical Impedance Spectroscopy (EIS). Researchers can study protein-protein interactions, receptor-ligand binding, enzyme-substrate interactions, and more, finding applications in drug discovery, biomarker identification, and understanding biological processes.

Global Label-free Array System Market Analysis

The global label-free array system market size was $455.91 million in 2022 and is predicted to grow at a CAGR of 7.42%, by generating a revenue of $919.68 million by 2032.

COVID-19 Impact on Global Label-free Array System Market

The COVID-19 pandemic had several impacts on the label-free array system market. Disruptions in the supply chain dueto factory closures and transportation restrictions ledto potential delays in production and increased costs for label-free array systems and related components. Additionally, the temporary decline in demand occurred as research institutions and pharmaceutical companies redirected their efforts towards COVID-19-related research, affecting the demand for label-free array systems for other research purposes. The pandemic also influenced the research priorities of the scientific community, with some areas being deprioritized while others, such as virology and immunology, received increased attention. Due to limitations on in-person events, the market had to adapt to virtual conferences and webinars, affecting product demonstrations and marketing. Financial constraints from the pandemic's economic impact may have influenced purchasing decisions for label-free array systems. Despite challenges, specific opportunities arose in COVID-19 research, as label-free array systems played a vital role in studying virus-host interactions, vaccine development, and drug discovery.

Advantages Over Traditional Methods to Drive the Market Growth

The label-free array system market is driven by various factors contributing to its growth. One key driver is its advantages over traditional methods, such as reduced sample preparation time, cost-effectiveness, and compatibility with complex samples. Moreover, the pharmaceutical and biotechnology industries' increasing demand for drug discovery and development fuels the adoption of label-free array systems for analyzing drug-target interactions and binding affinities. Additionally, the expanding research in proteomics and genomics, the rising prevalence of chronic diseases, and the need for personalized medicine further propel the market. Technological advancements, government, and private funding, academic research applications, and the growth of contract research organizations (CROs) utilizing label-free array systems also contribute to the market's positive outlook. Furthermore, the technology's exploration in diagnostics for biomarker detection adds to its market appeal.

High Manufacturing Cost to Restrain the Market Growth  

The label-free array system market faces several factors that may restrain its growth. One of the primary challenges is the high cost associated with developing, manufacturing, and purchasing these systems, which can deter potential buyers, especially in smaller research institutions. Additionally, there needs to be more awareness about the benefits and applications of label-free array systems, particularly in developing regions, leading to slower adoption rates. Established technologies like ELISA and mass spectrometry, which have been widely used, pose intense competition and may hinder the widespread adoption of label-free array systems. Furthermore, the complexity and expertise required to utilize these systems may limit their usage in specific settings. Technical limitations, regulatory hurdles, data interpretation challenges, and intellectual property concerns also add to the restraints in the market. Market players continually work on improving system performance and reducing costs to overcome these restraints and expand their market presence.

Drug Discovery and Development to Drive Excellent Opportunities

The label-free array system market was teeming with opportunities driven by several key factors. The foremost opportunity arose from the system's drug discovery and development applications, enabling high-throughput screening and cost-efficient identification of potential lead compounds. Additionally, label-free array systems played a crucial role in biomarker discovery, facilitating early disease detection and personalized medicine. Academic and research institutions embraced these systems to study molecular interactions and pathways. The biopharmaceutical industry also recognized their value, leveraging them to optimize therapeutic candidates and improve drug efficacy. Furthermore, technological advancements enhanced sensitivity, accuracy, and multiplexing capabilities, making these systems more attractive for various applications. Point-of-care diagnostics, food safety, and environmental monitoring were also promising markets. Additionally, emerging economies were experiencing growth in demand due to increasing investments in healthcare infrastructure and research capabilities.

Global Label-free Array System Market Share, by Type, 2022

The surface plasmon resonance sub-segment accounted for the highest market share in 2022. Surface Plasmon Resonance (SPR) technology has significantly impacted the label-free array system market. It is a powerful analytical technique for studying biomolecular interactions in real-time without fluorescent or radioactive labels. Researchers can study binding phenomena such as protein-protein interactions and antigen-antibody binding in a label-free, non-invasive manner. The high sensitivity and specificity of SPR allow detection of weak binding interactions and accurate measurement of binding affinities, making it valuable for drug development, biomarker research, and other applications. Its real-time monitoring capability provides dynamic information about association and dissociation rates of interactions. Some SPR systems also allow for multiplexing, enabling the simultaneous measurement of multiple interactions, which enhances experimental throughput. With applications in drug discovery, diagnostics, and various research fields, the demand for label-free array systems based on SPR technology has grown steadily, indicating its continued influence on the market.

Global Label-free Array System Market Share, by Application, 2022

The drug discovery sub-segment accounted for the highest market share in 2022. Drug discovery has played a pivotal role in dominating the label-free array system Market. Label-free array systems have become essential drug discovery and development tools, enabling researchers to study molecular interactions without labels. These systems facilitate high-throughput screening, allowing researchers to simultaneously assess the binding affinities and kinetics of numerous molecules, thus significantly speeding up the drug discovery process and reducing costs. Moreover, label-free array systems provide a deeper understanding of drug targets and their interactions with potential drug compounds, improving the optimization of drug candidates' efficacy and safety. This has led to increased academic and industrial research adoption, driving the market's growth. Furthermore, continuous technological advancements have enhanced label-free array systems' sensitivity, throughput, and user-friendliness, expanding their applications beyond drug discovery to areas such as diagnostics, proteomics, and biomarker discovery.

Global Label-free Array System Market Share, by End-user Scope, 2022

The pharmaceutical & biotechnology companies sub-segment accounted for the highest market share in 2022. Their dominance is attributed to several factors. First, these companies are constantly seeking innovative technologies to accelerate the drug discovery process, and label-free array systems provide real-time and high-throughput analysis of biomolecular interactions, aiding in drug-target studies and protein-protein interactions. Second, the rising demand for personalized medicine has fueled their interest in label-free array systems, as these technologies allow them to study patient-specific cellular responses and biomarkers for developing personalized therapies. Third, with the increasing prominence of biologics in the pharmaceutical industry, label-free array systems have become essential for characterizing and optimizing complex biologics like monoclonal antibodies and cell therapies. Additionally, the technological advancements in label-free array technology have made it more sensitive, reliable, and user-friendly, further encouraging their adoption by pharmaceutical and biotechnology companies. Their utilization of label-free array systems also gives them a competitive advantage in drug development, as it provides valuable insights into molecular interactions and cellular behavior, leading to identifying potential drug candidates with higher success rates in clinical trials.

Global Label-free Array System Market Share, by Region, 2022

The North America label-free array system market generated the highest revenue in 2022. North America has dominated the label-free array system market for several reasons. The region's leadership is attributed to its strong position in technological advancements in the life sciences and biotechnology sectors, with extensive research and development activities. North America houses many biopharmaceutical companies, and label-free array systems play a crucial role in drug discovery and development, fueling demand for such technologies. Additionally, government support and funding for life sciences research, along with the presence of world-renowned academic and research institutions, have accelerated the adoption of label-free array systems. Collaboration between industry players and academic institutions has further facilitated the market's growth, while North America's well-established healthcare infrastructure ensures efficient distribution to end-users. The region's prominent life sciences instrument manufacturers have also contributed to market dominance through competitive offerings and marketing efforts.

Competitive Scenario in the Global Label-free Array System Market

Investment and agreement are common strategies followed by major market players. One of the leading market players in the industry is ForteBio. In October 2022, ForteBio is a leading provider of label-free array systems, such as the Octet Red system, a label-free, real-time biosensor used to study protein-protein interactions, protein-ligand interactions, and protein stability. The system is widely used in pharmaceutical and biotechnology research to aid in discovering and developing new drugs. It is marketed and sold by Pall ForteBio in the United States.

Some of the leading label-free array system market players are Illumina Inc., Thermo Fisher Scientific Inc., Agilent Technologies Inc., PerkinElmer Inc., Merck KGaA, Danaher Corporation, Bio-Rad Laboratories Inc., ForteBio, F. Hoffmann-La Roche AG, Becton Dickinson and Company, and Sartorius AG.



Historical Market Estimations


Base Year for Market Estimation


Forecast Timeline for Market Projection


Geographical Scope

North America, Europe, Asia-Pacific, and LAMEA

Segmentation by Type

  • Surface Plasmon Resonance
  • Bio-layer Interferometry
  • Cellular Dielectric Spectroscopy
  • Others

Segmentation by Application

  • Drug Discovery
  • Protein Interface Analysis
  • Antibody Characterization
  • Others


Segmentation by End-user Scope



  • Pharmaceutical & Biotechnology Companies
  • Academic & Research Institutes
  • CRO
  • Others

Key Companies Profiled

  • Illumina Inc.
  • Thermo Fisher Scientific Inc.
  • Agilent Technologies Inc.
  • PerkinElmer Inc.
  • Merck KGaA
  • Danaher Corporation
  • Bio-Rad Laboratories Inc.
  • ForteBio
  • F. Hoffmann-La Roche AG
  • Becton Dickinson and Company
  • Sartorius AG 

Frequently Asked Questions

A. The size of the global label-free array system market was over $455.91 million in 2022 and is projected to reach $919.68 million by 2032.

A. Becton Dickinson and Company and Sartorius AG. are some of the key players in the global label-free array system market.

A. The North America region possesses great investment opportunities for investors to witness the most promising growth in the future.

A. Agreement and investment are the two key strategies opted by the operating companies in this market.

A. Agilent Technologies Inc., PerkinElmer Inc., Merck KGaA, Danaher Corporation, and Bio-Rad Laboratories Inc. are the companies investing more in R&D activities for developing new products and technologies.

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